(S)-(4-(benzyloxy)-4-oxobutanoyloxy)methyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate

Base Information

Chemical Name:(S)-(4-(benzyloxy)-4-oxobutanoyloxy)methyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate
CAS No.:864775-17-7
Molecular Formula:C₂₉H₂₂ClF₄NO₈
Molecular Weight:623.942
Hs Code.:

Synonyms:(S)-(4-(benzyloxy)-4-oxobutanoyloxy)methyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate

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Chemical Property of (S)-(4-(benzyloxy)-4-oxobutanoyloxy)methyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate

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Technology Process of (S)-(4-(benzyloxy)-4-oxobutanoyloxy)methyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate

There total 1 articles about (S)-(4-(benzyloxy)-4-oxobutanoyloxy)methyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 103-40-2
succinic acid monobenzyl ester

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 187523-35-9,187523-36-0
(S)-(+)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one

: 864775-17-7
(S)-(4-(benzyloxy)-4-oxobutanoyloxy)methyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate

Guidance literature:: carbonochloridic acid, chloromethyl ester; (S)-(+)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one; With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃;

With sodium iodide; In acetone; for 6h; Heating / reflux;

succinic acid monobenzyl ester; With caesium carbonate; In acetonitrile; at 20 ℃; for 3h;