N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid

Base Information

Chemical Name:N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid
CAS No.:129780-79-6
Molecular Formula:C₂₀H₂₁N₇O₅
Molecular Weight:439.431
Hs Code.:

Synonyms:N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid

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Chemical Property of N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid

Chemical Property:

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Technology Process of N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid

There total 3 articles about N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 129780-82-1
di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

: 129780-79-6
N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm00105a036

Reference yield:

: 10541-83-0,937737-33-2
N-methyl-p-aminobenzoic acid

: 129780-79-6
N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / i-Pr₂NEt / dimethylformamide / 1.5 h / Ambient temperature

2: 89 percent / 2-ethoxy-ethanol / 1 h / 135 °C

3: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, RT, 20 min

4: 61 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

With diethyl cyanophosphonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00105a036

Reference yield:

: 40127-91-1
2-Amino-5-chloromethylpyrazine-3-carbonitrile

: 129780-79-6
N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / i-Pr₂NEt / dimethylformamide / 1.5 h / Ambient temperature

2: 89 percent / 2-ethoxy-ethanol / 1 h / 135 °C

3: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, RT, 20 min

4: 61 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

With diethyl cyanophosphonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00105a036