5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Base Information

• Chemical Name: 5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
• CAS No.: 1429012-27-0
• Molecular Formula: C₁₃H₈F₃N₃S
• Molecular Weight: 295.288
• Mol file: 1429012-27-0.mol

Synonyms:5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Chemical Property of 5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

There total 1 articles about 5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) + formamide (77287-34-4,77287-35-5,60100-09-6) + malononitrile (109-77-3) → 5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine (1429012-27-0)

Guidance literature:

With sulfur; disodium hydrogenphosphate; triphenylphosphine; at 200 ℃; for 0.5h;

DOI:10.1002/ejoc.201900414

Reference yield:

5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine (1429012-27-0) + orthoformic acid triethyl ester (122-51-0) + phosphonic acid diethyl ester (762-04-9) → C22H28F3N3O6P2S

Guidance literature:

In toluene; at 130 ℃; for 48h; Inert atmosphere; Sealed tube; Darkness;

DOI:10.1016/j.bmc.2013.02.006

Reference yield:

5-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine (1429012-27-0) → C14H12F3N3O6P2S

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 48 h / 130 °C / Inert atmosphere; Sealed tube; Darkness

2: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With trimethylsilyl bromide; In dichloromethane; toluene;

DOI:10.1016/j.bmc.2013.02.006

upstream raw materials:

1-(4-trifluoromethylphenyl)ethanone

formamide

malononitrile