(3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Base Information

Chemical Name:(3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid
CAS No.:943345-15-1
Molecular Formula:C₂₆H₁₉N₃O₅
Molecular Weight:453.454
Hs Code.:

Synonyms:(3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

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Chemical Property of (3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

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Technology Process of (3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

There total 9 articles about (3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943345-06-0
3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

: 943345-15-1
(3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Guidance literature:: 3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid; With boron tribromide; In dichloromethane; at 20 ℃;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 554-84-7
meta-nitrophenol

: 943345-15-1
(3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / acetone / 1 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Inert atmosphere

3.1: 1.5 h / 150 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

4.2: Cooling with ice

5.1: boron tribromide / dichloromethane / 20 °C

With water; hydrogen; boron tribromide; caesium carbonate; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetone;

Reference yield:

: 81720-19-6
1-methoxycarbonylmethyloxy-3-nitrobenzene

: 943345-15-1
(3-{[5-(4-Hydroxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Inert atmosphere

2.1: 1.5 h / 150 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

3.2: Cooling with ice

4.1: boron tribromide / dichloromethane / 20 °C

With water; hydrogen; boron tribromide; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;