1-[N²-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine

Base Information

• Chemical Name: 1-[N²-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine
• CAS No.: 204697-12-1
• Molecular Formula: C₄₂H₅₅Br₂N₉O₇
• Molecular Weight: 957.763

Synonyms:1-[N²-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine

Chemical Property of 1-[N²-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine

Chemical Property:

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Technology Process of 1-[N²-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine

There total 9 articles about 1-[N²-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[N-(aminocarbonyl)phenylamino]-1-phenylmethylpiperidine (864738-99-8) → 1-[N2-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine (204697-12-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / H₂ / Pd(OH)2 / methanol / 50 °C

2.1: tetrahydrofuran / 3 h / 20 °C

2.2: tetrahydrofuran / 2 h / Heating

With hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol;

DOI:10.1021/jm0490641

Reference yield:

1-[N2-(phenylmethoxycarbonyl)-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine (204692-51-3) → 1-[N2-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine (204697-12-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 97 percent / H₂; aq. potassium hydrogenesulfate / Pd/C / methanol / 20 °C / 2250.18 Torr

2.1: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

3.1: 68 percent / diethylamine / methanol / 5 h / 60 °C

4.1: tetrahydrofuran / 3 h / 20 °C

4.2: tetrahydrofuran / 2 h / Heating

With potassium hydrogensulfate; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0490641

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → 1-[N2-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine (204697-12-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

2.1: 97 percent / H₂; aq. potassium hydrogenesulfate / Pd/C / methanol / 20 °C / 2250.18 Torr

3.1: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

4.1: 68 percent / diethylamine / methanol / 5 h / 60 °C

5.1: tetrahydrofuran / 3 h / 20 °C

5.2: tetrahydrofuran / 2 h / Heating

With potassium hydrogensulfate; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0490641

upstream raw materials:

4-[N-(aminocarbonyl)-phenylamino]piperidine

1,1'-Carbonyl-di-(1,2,4-triazole)

1-[N²-(3,5-dibromo-D-tyrosyl)-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

4-[N-(aminocarbonyl)phenylamino]-1-phenylmethylpiperidine

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