(S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide

Base Information

Chemical Name:(S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide
CAS No.:1628224-55-4
Molecular Formula:C₂₄H₂₀F₆N₄O₂
Molecular Weight:510.439
Hs Code.:

Synonyms:(S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide

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Chemical Property of (S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide

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Technology Process of (S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide

There total 4 articles about (S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1628224-53-2
(S)-tert-butyl (1-((2'-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)-[1,1'-biphenyl]-2-yl)amino)-1-oxopropan-2-yl)carbamate

: 1628224-55-4
(S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1002/cjoc.201400166

Reference yield:

: 2436-96-6
1-nitro-2-(2-nitrophenyl)benzene

: 1628224-55-4
(S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 757.58 Torr

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3.5 h / 0 - 20 °C

3: dichloromethane / 16 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1002/cjoc.201400166

Reference yield:

: 1628224-52-1
(S)-tert-butyl (1-((2'-amino-[1,1'-biphenyl]-2-yl)amino)-1-oxopropan-2-yl)carbamate

: 1628224-55-4
(S)-2-amino-N-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-[1,1'-biphenyl]-2-yl)-propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 16 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1002/cjoc.201400166