methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

Base Information

Chemical Name:methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate
CAS No.:1004396-44-4
Molecular Formula:C₂₀H₁₉N₃O₄S
Molecular Weight:397.455
Hs Code.:

Synonyms:methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

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Chemical Property of methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

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Technology Process of methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

There total 3 articles about methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 69001-73-6
2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetic acid

: 1004396-44-4
methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetonitrile; at -5 - 20 ℃; for 10h;
DOI:10.1248/cpb.c14-00158

Reference yield:

: 37641-50-2
3-(4-methylphenyl)-2-thioxoquinazolin-4-one

: 1004396-44-4
methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 2 h / 25 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In ethanol; acetonitrile;
DOI:10.1248/cpb.c14-00158

Reference yield:

: 28831-25-6
(4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid methyl ester

: 1004396-44-4
methyl 2-(2-(4-oxo-3-p-tolyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol / 3 h / 25 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; water; acetonitrile;
DOI:10.1248/cpb.c14-00158