3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Base Information

Chemical Name:3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione
CAS No.:1335107-08-8
Molecular Formula:C₃₀H₂₈ClN₅O₂
Molecular Weight:526.038
Hs Code.:

Synonyms:3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

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Chemical Property of 3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

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Technology Process of 3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

There total 3 articles about 3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₄ClN₅O₃

: 1335107-08-8
3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Guidance literature:: C₃₂H₃₄ClN₅O₃; With potassium hydroxide; In methanol; at 120 ℃; for 0.25h; under 7757.43 Torr; Microwave irradiation; Sealed tube;

With acetic acid; In methanol; at 22 ℃; pH=4;
DOI:10.1016/j.bmc.2011.06.043

Reference yield:

: 1335106-96-1
2-[[[(2-chloroethyl)amino]carbonyl]amino]-4,5-diphenyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 1335107-08-8
3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; sodium iodide / tetrahydrofuran / 24 h / Reflux

2.1: potassium hydroxide / methanol / 0.25 h / 120 °C / 7757.43 Torr / Microwave irradiation; Sealed tube

2.2: 22 °C / pH 4

With sodium hydrogencarbonate; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2011.06.043

Reference yield:

: 111222-42-5
2-Amino-4,5-diphenyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 1335107-08-8
3-[2-[4-(2-chlorophenyl)-1-piperazinyl]ethyl]-5,6-diphenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; sodium iodide / toluene / 6 h / Reflux

2.1: sodium hydrogencarbonate; sodium iodide / tetrahydrofuran / 24 h / Reflux

3.1: potassium hydroxide / methanol / 0.25 h / 120 °C / 7757.43 Torr / Microwave irradiation; Sealed tube

3.2: 22 °C / pH 4

With sodium hydrogencarbonate; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.bmc.2011.06.043