3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione

Base Information

• Chemical Name: 3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione
• CAS No.: 1374601-07-6
• Molecular Formula: C₂₃H₂₂F₃N₃O₂
• Molecular Weight: 429.442

Synonyms:3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione

Chemical Property of 3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione

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Technology Process of 3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione

There total 3 articles about 3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-(2-propynyl)-1-cyclopentanecarboxylic acid (1242265-30-0) + 2-amino-N'-(3-(trifluoromethyl)phenyl)benzohydrazide (1351442-61-9) → 3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione (1374601-07-6)

Guidance literature:

With triphenylphosphinegold(I) triflate; In 1,2-dichloro-ethane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201101822

Reference yield:

isatoic anhydride (118-48-9) → 3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione (1374601-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Inert atmosphere; Reflux

2: triphenylphosphinegold(I) triflate / 1,2-dichloro-ethane / 24 h / 100 °C / Inert atmosphere

With triphenylphosphinegold(I) triflate; In ethanol; 1,2-dichloro-ethane;

DOI:10.1002/ejoc.201101822

Reference yield:

3-(trifluoromethyl)phenylhydrazine (368-78-5) → 3a'-methyl-4'-(3-trifluoromethyl)phenylamino-3a',4'-dihydro-1'Hspiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione (1374601-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Inert atmosphere; Reflux

2: triphenylphosphinegold(I) triflate / 1,2-dichloro-ethane / 24 h / 100 °C / Inert atmosphere

With triphenylphosphinegold(I) triflate; In ethanol; 1,2-dichloro-ethane;

DOI:10.1002/ejoc.201101822

upstream raw materials:

1-(2-propynyl)-1-cyclopentanecarboxylic acid

2-amino-N'-(3-(trifluoromethyl)phenyl)benzohydrazide

isatoic anhydride

3-(trifluoromethyl)phenylhydrazine

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