(3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Base Information

• Chemical Name: (3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide
• CAS No.: 107608-68-4
• Molecular Formula: C₂₄H₂₁N₇O₄S
• Molecular Weight: 503.541
• Mol file: 107608-68-4.mol

Synonyms:(3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Chemical Property of (3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

There total 4 articles about (3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + (3-Methyl-7-β-phenylethylxanthinyl-8) thioacetic hydrazide (107608-60-6) → (3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide (107608-68-4)

Guidance literature:

With acetic acid; In ethanol; Heating;

DOI:10.1007/BF00763698

Reference yield:

3-Methyl-7-β-phenylethyl-8-bromxanthine (101071-99-2) → (3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide (107608-68-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / dimethylformamide / 4 h / Heating

2: 73 percent / conc. aq. H₂SO₄ / 1.5 h

3: 69 percent / hydrazine hydrate / ethanol / 0.67 h / Heating

4: 100 percent / glacial AcOH / aq. ethanol / Heating

With sulfuric acid; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/BF00763698

Reference yield:

(3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid (107608-57-1) → (3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide (107608-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / conc. aq. H₂SO₄ / 1.5 h

2: 69 percent / hydrazine hydrate / ethanol / 0.67 h / Heating

3: 100 percent / glacial AcOH / aq. ethanol / Heating

With sulfuric acid; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1007/BF00763698

upstream raw materials:

indole-2,3-dione

(3-Methyl-7-β-phenylethylxanthinyl-8) thioacetic hydrazide

3-Methyl-7-β-phenylethyl-8-bromxanthine

(3-Methyl-2,6-dioxo-7-phenethyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetic acid