ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate

Base Information

• Chemical Name: ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate
• CAS No.: 1372787-26-2
• Molecular Formula: C₃₀H₂₉NO₅
• Molecular Weight: 483.564
• Mol file: 1372787-26-2.mol

Synonyms:ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate

Chemical Property of ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate

There total 4 articles about ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]-ethyl methanesulfonate (1034021-20-9) + ethyl 2-(3-hydroxyphenoxy)acetate (68747-24-0) → ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate (1372787-26-2)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.11.079

Reference yield:

2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethyl acetate (1356397-87-9) → ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate (1372787-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sodium hydroxide / ethanol / 1 h / 5 - 20 °C

2: triethylamine / dichloromethane / 1 h / 5 - 20 °C

3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

With water; potassium carbonate; triethylamine; sodium iodide; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.11.079

Reference yield:

5-(diphenylmethyl)-1-(2-hydroxyethyl)pyridin-2(1H)-one (1034021-92-5) → ethyl (3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetate (1372787-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 5 - 20 °C

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

With potassium carbonate; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.11.079

upstream raw materials:

2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethyl acetate

5-(diphenylmethyl)-1-(2-hydroxyethyl)pyridin-2(1H)-one

2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]-ethyl methanesulfonate

ethyl 2-(3-hydroxyphenoxy)acetate

Downstream raw materials:

(3-{2-[5-(diphenylmethyl)-2-oxopyridin-1(2H)-yl]ethoxy}phenoxy)acetic acid