(R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Base Information

Chemical Name:(R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate
CAS No.:1300217-20-2
Molecular Formula:C₂HF₃O₂*C₂₂H₂₂Cl₂N₄O₃S
Molecular Weight:607.438
Hs Code.:

Synonyms:(R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate

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Chemical Property of (R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate

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Technology Process of (R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate

There total 3 articles about (R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: (S)-2-amino-N-(2-amino-thiazol-5-ylmethyl)-3-(3,4-dichloro-phenyl)-propionamide dihydrochloride

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 76-05-1
trifluoroacetic acid

: 1300217-20-2
(R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Guidance literature:: (S)-2-amino-N-(2-amino-thiazol-5-ylmethyl)-3-(3,4-dichloro-phenyl)-propionamide dihydrochloride; D-phenyllactic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.25h;

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 114873-13-1,80741-39-5
N^α-[(tert-butoxy)carbonyl]-3,4-dichloro-L-phenylalanine

: 1300217-20-2
(R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.33 h

1.2: 0.33 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C

3.2: 18 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1300217-18-8
[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 1300217-20-2
(R)-N-[(S)-1-[(2-amino-thiazol-5-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C

2.2: 18 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;