[(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid

Base Information

Chemical Name:[(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid
CAS No.:1613300-07-4
Molecular Formula:C₂₈H₂₇FO₇
Molecular Weight:494.517
Hs Code.:

Synonyms:[(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid

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Chemical Property of [(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid

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Technology Process of [(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid

There total 13 articles about [(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613300-79-0
[(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid methyl ester

: 1613300-07-4
[(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid

Guidance literature:: With methanol; water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield:

: 146631-00-7
[4-(benzyloxy)phenyl]boronic acid

: 1613300-07-4
[(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; copper diacetate; oxygen / dichloromethane / 20 °C / 750.08 Torr / Molecular sieve; Sealed tube

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

4: sodium hydroxide; methanol; water / tetrahydrofuran / 6 h / 20 °C

With methanol; palladium 10% on activated carbon; water; hydrogen; oxygen; copper diacetate; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1458652-59-9
methyl 2-((S)-6-((R)-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1613300-07-4
[(S)-6-{(R)-7-fluoro-4-[4-(2-methoxyethoxy)phenoxy]indan-1-yloxy}-2,3-dihydrobenzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dihydrogen peroxide / acetic acid; water / 2.5 h / 20 °C / Cooling

2: triethylamine; copper diacetate; oxygen / dichloromethane / 20 °C / 750.08 Torr / Molecular sieve; Sealed tube

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

5: sodium hydroxide; methanol; water / tetrahydrofuran / 6 h / 20 °C

With methanol; palladium 10% on activated carbon; water; hydrogen; dihydrogen peroxide; oxygen; copper diacetate; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;