(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate

Base Information

Chemical Name:(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate
CAS No.:1609075-07-1
Molecular Formula:C₃₇H₃₈BrN₅O₇
Molecular Weight:744.642
Hs Code.:

Synonyms:(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate

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Chemical Property of (4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate

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Technology Process of (4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate

There total 4 articles about (4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 153984-96-4
4-nitrophenyl N-trityl-L-phenylalanyl-L-leucylglycinate

: 91421-50-0
9-bromo-(20S)-camptothecin

: 1609075-07-1
(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate

Guidance literature:: With dmap; In dimethyl sulfoxide; at 20 ℃; for 72h;

Reference yield:

: 1609075-27-5
L-valyl-N-{[1-(2-{[(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4’:6,7]indolizino[1,2-b]quinolin-4-yl]oxy}-2-oxoethyl)cyclohexyl]methyl}-N⁵-carbamoyl-L-ornithinamide

: 1609075-07-1
(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 3 h / 20 °C

1.2: 0.33 h / 20 °C

2.1: diethylenetriaminopentaacetic acid; sodium chloride / aq. buffer / 1 h / 21 °C

3.1: cathepsin B / aq. buffer / 20 - 40 °C

4.1: dmap / dimethyl sulfoxide / 72 h / 20 °C

With dmap; diethylenetriaminopentaacetic acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium chloride; cathepsin B; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: C₅₃H₆₈BrN₉O₁₃S

: 1609075-07-1
(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl L-phenylalanyl-L-leucylglycinate

Guidance literature:: Multi-step reaction with 2 steps

1: cathepsin B / aq. buffer / 20 - 40 °C

2: dmap / dimethyl sulfoxide / 72 h / 20 °C

With dmap; cathepsin B; In dimethyl sulfoxide;