1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone

Base Information

Chemical Name:1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone
CAS No.:871816-09-0
Molecular Formula:C₁₅H₁₇N₃O₂
Molecular Weight:271.319
Hs Code.:

Synonyms:1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone

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Chemical Property of 1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone

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Technology Process of 1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone

There total 8 articles about 1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 871816-07-8
(5S)-(1H-imidazol-1-ylmethyl)-1-[[3-(phenylmethoxy)phenyl]methyl]-2-pyrrolidinone

: 871816-09-0
1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 1308718-80-0
(2S)-5-oxo-1-[(3-phenylmethoxyphenyl)methyl]pyrrolidine-2-carboxylic acid methyl ester

: 871816-09-0
1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 50 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol

With lithium borohydride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 871816-02-3
(5S)-(hydroxymethyl)-1-[[3-(phenylmethoxy)phenyl]methyl]-2-pyrrolidinone

: 871816-09-0
1-[(3-hydroxyphenyl)methyl]-(5S)-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: N,N-dimethyl-formamide / 50 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.044