cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate

Base Information

• Chemical Name: cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate
• CAS No.: 1023699-81-1
• Molecular Formula: C₂₆H₂₈N₄O₄S
• Molecular Weight: 492.599
• Mol file: 1023699-81-1.mol

Synonyms:cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate

Chemical Property of cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate

There total 1 articles about cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-[(aminocarbonyl)amino]-5-[4-formylphenyl]thiophene-3-carboxamide (494773-25-0) + (1S)-2-(cyclopentyloxy)-2-oxo-1-phenylethanaminium 4-methylbenzenesulfonate (914604-52-7) → cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate (1023699-81-1)

Guidance literature:

2-[(aminocarbonyl)amino]-5-[4-formylphenyl]thiophene-3-carboxamide; (1S)-2-(cyclopentyloxy)-2-oxo-1-phenylethanaminium 4-methylbenzenesulfonate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.0833333h;

With acetic acid; In tetrahydrofuran; for 0.166667h;

With MP-CNBH₃; ammonia; more than 3 stages;

Reference yield: 60.0%

cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate (1023699-81-1) → (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetic acid (1023700-35-7)

Guidance literature:

cyclopentyl (2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate; With lithium hydroxide; water; In tetrahydrofuran; at 20 - 40 ℃;

With water; acetic acid;

upstream raw materials:

2-[(aminocarbonyl)amino]-5-[4-formylphenyl]thiophene-3-carboxamide

(1S)-2-(cyclopentyloxy)-2-oxo-1-phenylethanaminium 4-methylbenzenesulfonate

Downstream raw materials:

(2S)-({4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetic acid