benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate

Base Information

• Chemical Name: benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate
• CAS No.: 936730-82-4
• Molecular Formula: C₂₅H₂₉N₃O₇
• Molecular Weight: 483.521

Synonyms:benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate

Chemical Property of benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate

There total 2 articles about benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (5S,8S)-5-methyl-3,6,13-trioxo-1-phenyl-2-oxa-4,7,12-triazapentadec-14-ene-8-carboxylate (936730-80-2) → benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate (936730-82-4)

Guidance literature:

benzyl (5S,8S)-5-methyl-3,6,13-trioxo-1-phenyl-2-oxa-4,7,12-triazapentadec-14-ene-8-carboxylate; With ozone; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at 25 ℃; for 12h; Further stages.;

DOI:10.1021/ol070275k

Reference yield:

(S)-5-Amino-2-((S)-2-benzyloxycarbonylamino-propionylamino)-pentanoic acid benzyl ester; hydrochloride → benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate (936730-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 93 percent / TMP / CH₂Cl₂ / 4 h / 0 °C

2.1: ozone / CH₂Cl₂; methanol / -78 °C

2.2: dimethyl sulfide / CH₂Cl₂; methanol / 12 h / 25 °C

With thymidine 5'-phosphate; ozone; In methanol; dichloromethane;

DOI:10.1021/ol070275k

Reference yield: 34.0%

C16H27ONSSi (936730-79-9) + benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate (936730-82-4) → benzyl (5S,8S)-5-methyl-3,6,13-trioxo-13-(4-oxo-3-propyloxetan-2-yl)-1-phenyl-2-oxa-4,7,12-triazatridecane-8-carboxylate

Guidance literature:

With zinc(II) chloride; In dichloromethane; at 25 ℃;

DOI:10.1021/ol070275k

upstream raw materials:

benzyl (5S,8S)-5-methyl-3,6,13-trioxo-1-phenyl-2-oxa-4,7,12-triazapentadec-14-ene-8-carboxylate

Downstream raw materials:

C₃₁H₃₉N₃O₈

(2S)-[(2S)-benzyloxycarbonylaminopropionylamino]-5-{[(3S)-((1S)-methylpropyl)-4-oxooxetane-(2R)-carbonyl]amino}pentanoic acid benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 936730-82-4 benzyl (5S,8S)-5-methyl-3,6,13,14-tetraoxo-1-phenyl-2-oxa-4,7,12-triazatetradecane-8-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send