ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate

Base Information

• Chemical Name: ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate
• CAS No.: 188564-68-3
• Molecular Formula: C₂₄H₃₁O₉P
• Molecular Weight: 494.479
• Mol file: 188564-68-3.mol

Synonyms:ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate

Chemical Property of ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate

There total 1 articles about ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

ethyl 2-diazo-2-(diethoxyphosphoryl)acetate (17507-56-1) + ethyl 4-benzyloxy-3-hydroxybenzoate (177429-27-5) → ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate (188564-68-3)

Guidance literature:

With rhodium(II) acetate; In benzene; Heating;

DOI:10.1016/S0968-0896(96)00239-8

Reference yield: 95.0%

ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate (188564-68-3) → ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-hydroxybenzoate (188564-69-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h;

DOI:10.1016/S0968-0896(96)00239-8

Reference yield:

ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-(phenylmethoxy)benzoate (188564-68-3) → 2-[5-Carboxy-3-(carboxy-phosphono-methoxy)-2-hydroxy-phenyl]-2-hydroxy-malonic acid

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10percent Pd/C / ethanol / 2 h

2: 30 percent / SnCl₄ / CH₂Cl₂ / 36 h / 20 °C

3: TMSBr, pyridine / CH₂Cl₂ / 3 h / Ambient temperature

4: aq. NaOH / 18 h / Ambient temperature

With pyridine; sodium hydroxide; trimethylsilyl bromide; hydrogen; tin(IV) chloride; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1016/S0968-0896(96)00239-8

upstream raw materials:

ethyl 2-diazo-2-(diethoxyphosphoryl)acetate

ethyl 4-benzyloxy-3-hydroxybenzoate

Downstream raw materials:

ethyl 3-[1-(diethoxyphosphinyl)-2-ethoxy-2-oxoethoxy]-4-hydroxybenzoate