1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole

Base Information

Chemical Name:1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
CAS No.:1445859-44-8
Molecular Formula:C₁₆H₁₉N₃O₆
Molecular Weight:349.343
Hs Code.:

Synonyms:1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole

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Chemical Property of 1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole

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Technology Process of 1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole

There total 5 articles about 1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₅N₃O₅

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1445859-44-8
1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.05.016

Reference yield:

: 1445859-28-8
1-(6-nitro-2,3,4-trimethoxyphenyl)prop-2-en-1-ol

: 1445859-44-8
1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent / acetone / 0.17 h / 20 °C

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With Jones reagent; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; acetone;
DOI:10.1016/j.bmc.2013.05.016

Reference yield:

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1445859-44-8
1-cyclopropylcarbonyl-3-(6-nitro-2,3,4-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; acetic acid

2: tetrahydrofuran / 3.5 h / -70 °C

3: Jones reagent / acetone / 0.17 h / 20 °C

4: hydrazine hydrate / ethanol / 3 h / Reflux

5: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With Jones reagent; nitric acid; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1016/j.bmc.2013.05.016