(S)-1-fluoro-1,2-diphenylethyl benzoate

Base Information

Chemical Name:(S)-1-fluoro-1,2-diphenylethyl benzoate
CAS No.:1588768-25-5
Molecular Formula:C₂₁H₁₇FO₂
Molecular Weight:320.363
Hs Code.:

Synonyms:(S)-1-fluoro-1,2-diphenylethyl benzoate

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Chemical Property of (S)-1-fluoro-1,2-diphenylethyl benzoate

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Technology Process of (S)-1-fluoro-1,2-diphenylethyl benzoate

There total 7 articles about (S)-1-fluoro-1,2-diphenylethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1588767-30-9
(S)-2-fluoro-1,2,3-triphenylpropan-1-one

: 1588768-25-5
(S)-1-fluoro-1,2-diphenylethyl benzoate

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; 3-chloro-benzenecarboperoxoic acid; In aq. phosphate buffer; dichloromethane; at 20 ℃; for 36h; pH=7; regioselective reaction; Inert atmosphere;
DOI:10.1021/ja501815p

Reference yield:

: 28557-00-8
phenylzinc chloride

: 1588768-25-5
(S)-1-fluoro-1,2-diphenylethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,2-dimethoxyethane)dichloronickel(II); 2,2'-methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline] / tetrahydrofuran; diethylene glycol dimethyl ether / 0.42 h / -25 °C / Inert atmosphere

1.2: 36 h / -20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid; 1,1,1,3',3',3'-hexafluoro-propanol / dichloromethane; aq. phosphate buffer / 36 h / 20 °C / pH 7 / Inert atmosphere

With (1,2-dimethoxyethane)dichloronickel(II); 1,1,1,3',3',3'-hexafluoro-propanol; 3-chloro-benzenecarboperoxoic acid; 2,2'-methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline]; In tetrahydrofuran; aq. phosphate buffer; dichloromethane; diethylene glycol dimethyl ether; 1.2: |Negishi Coupling / 2.1: |Baeyer-Villiger Ketone Oxidation;
DOI:10.1021/ja501815p

Reference yield:

: 1083-30-3
dihydrochalcone

: 1588768-25-5
(S)-1-fluoro-1,2-diphenylethyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: (1,2-dimethoxyethane)dichloronickel(II); 2,2'-methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline] / tetrahydrofuran; diethylene glycol dimethyl ether / 0.42 h / -25 °C / Inert atmosphere

3.2: 36 h / -20 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid; 1,1,1,3',3',3'-hexafluoro-propanol / dichloromethane; aq. phosphate buffer / 36 h / 20 °C / pH 7 / Inert atmosphere

With n-butyllithium; (1,2-dimethoxyethane)dichloronickel(II); 1,1,1,3',3',3'-hexafluoro-propanol; trimethylsilyl trifluoromethanesulfonate; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 2,2'-methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline]; In tetrahydrofuran; aq. phosphate buffer; hexane; dichloromethane; diethylene glycol dimethyl ether; 3.2: |Negishi Coupling / 4.1: |Baeyer-Villiger Ketone Oxidation;
DOI:10.1021/ja501815p