4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene

Base Information

• Chemical Name: 4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene
• CAS No.: 90858-24-5
• Molecular Formula: C₂₁H₃₀O
• Molecular Weight: 298.469
• Mol file: 90858-24-5.mol

Synonyms:4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene

Chemical Property of 4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene

There total 3 articles about 4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(+/-)-1-<2-(2-Methoxy-5-isopropylphenyl)-1-hydroxyethyl>-2,6,6-trimethylcyclohexene (90858-23-4) → 4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene (90858-24-5)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; for 1h; Ambient temperature;

DOI:10.1021/jo00190a038

Reference yield:

2,6,6-trimethylcyclohex-1-enecarbaldehyde (432-25-7) → 4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene (90858-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / sodium naphthalenide / tetrahydrofuran / 2 h / -5 °C

2: 84 percent / LiAlH₄, AlCl₃ / diethyl ether / 1 h / Ambient temperature

With lithium aluminium tetrahydride; aluminium trichloride; sodium naphthalenide; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00190a038

Reference yield:

2-Methoxy-5-isopropylbenzyl chloride (22252-69-3) → 4-Isopropyl-1-methoxy-2-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-benzene (90858-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / sodium naphthalenide / tetrahydrofuran / 2 h / -5 °C

2: 84 percent / LiAlH₄, AlCl₃ / diethyl ether / 1 h / Ambient temperature

With lithium aluminium tetrahydride; aluminium trichloride; sodium naphthalenide; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00190a038

upstream raw materials:

(+/-)-1-<2-(2-Methoxy-5-isopropylphenyl)-1-hydroxyethyl>-2,6,6-trimethylcyclohexene

2,6,6-trimethylcyclohex-1-enecarbaldehyde

2-Methoxy-5-isopropylbenzyl chloride

Downstream raw materials:

2-(2,6,6-Trimethyl-1-cyclohexenyl)-1-(2-hydroxy-5-isopropylphenyl)ethane

2-(2,6,6-Trimethyl-1-cyclohexenyl)-1-(2-methoxy-5-isopropylphenyl)ethane