(2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate

Base Information

Chemical Name:(2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate
CAS No.:136707-46-5
Molecular Formula:C₂₁H₃₃NO₅S
Molecular Weight:411.563
Hs Code.:

Synonyms:(2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate

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Chemical Property of (2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate

Chemical Property:

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Technology Process of (2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate

There total 6 articles about (2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136707-37-4
(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(4'-iodobutyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 136707-46-5
(2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80.6 percent / dimethylformamide / 4 h / 80 °C

2: H₂ / PdCl₂ / tetrahydrofuran; ethanol / 20 h / 2585.7 Torr

3: 1 N HCl / 2 h / Heating

4: 83 percent / Et₃N, DMAP / H₂O; acetonitrile / 24 h

5: 93.8 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h

6: 1.) NaOEt / 1.) EtOH, 20 min, 2.) EtOH, THF, 45 min

With hydrogenchloride; dmap; hydrogen; sodium ethanolate; triethylamine; palladium dichloride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00024a038

Reference yield:

: 136707-39-6
(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<4'-(acetyloxy)butyl>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 136707-46-5
(2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / PdCl₂ / tetrahydrofuran; ethanol / 20 h / 2585.7 Torr

2: 1 N HCl / 2 h / Heating

3: 83 percent / Et₃N, DMAP / H₂O; acetonitrile / 24 h

4: 93.8 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h

5: 1.) NaOEt / 1.) EtOH, 20 min, 2.) EtOH, THF, 45 min

With hydrogenchloride; dmap; hydrogen; sodium ethanolate; triethylamine; palladium dichloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00024a038

Reference yield:

: 136707-42-1
(2R)-ethyl 2-amino-6-hydroxyheptanoate hydrochloride

: 136707-46-5
(2R)-ethyl 2-(tert-butyloxycarbonyl)amino-6-<(p-methoxybenzyl)thio>heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Et₃N, DMAP / H₂O; acetonitrile / 24 h

2: 93.8 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h

3: 1.) NaOEt / 1.) EtOH, 20 min, 2.) EtOH, THF, 45 min

With dmap; sodium ethanolate; triethylamine; In dichloromethane; water; acetonitrile;
DOI:10.1021/ja00024a038