2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester

Base Information

Chemical Name:2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester
CAS No.:947171-06-4
Molecular Formula:C₂₃H₂₈NO₈P
Molecular Weight:477.451
Hs Code.:

Synonyms:2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester

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Chemical Property of 2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester

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Technology Process of 2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester

There total 5 articles about 2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 947171-03-1
(4-(N-benzyloxycarbonylamino)phenyl)phosphinic acid methyl ester

: 5621-44-3
dimethyl 2-methylenepentanedioate

: 947171-06-4
2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester

Guidance literature:: (4-(N-benzyloxycarbonylamino)phenyl)phosphinic acid methyl ester; dimethyl 2-methylenepentanedioate; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; for 168h; Heating;

With water; In dichloromethane; for 0.5h; Further stages.;
DOI:10.1021/jo0707840

Reference yield: 33.0%

: 947171-03-1
(4-(N-benzyloxycarbonylamino)phenyl)phosphinic acid methyl ester

: 5621-44-3
dimethyl 2-methylenepentanedioate

: 947171-06-4
2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester

: 947171-09-7
C₁₇H₂₄NPO₈

Guidance literature:: With sodium methylate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo0707840

Reference yield:

: 93298-14-7
(4-iodophenyl)carbamic acid phenylmethyl ester

: 947171-06-4
2-[((4-(N-benzyloxycarbonylamino)phenyl)(methoxy)phosphinoyl)methyl]pentane-1,5-dioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 71 percent / DABCO; anilinium hypophosphite; 1,3-bis(diphenylphosphino)propane / palladium acetate / acetonitrile / 2 h / 85 °C

2.1: N,O-bis(trimethylsilyl)acetamide / CH₂Cl₂ / 168 h / Heating

2.2: 71 percent / water / CH₂Cl₂ / 0.5 h

With 1,4-diaza-bicyclo[2.2.2]octane; N,O-bis-(trimethylsilyl)-acetamide; anilinium hypophosphorous salt; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In dichloromethane; acetonitrile;
DOI:10.1021/jo0707840