piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester

Base Information

• Chemical Name: piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester
• CAS No.: 199452-41-0
• Molecular Formula: C₁₄H₁₈BrN₃O₄
• Molecular Weight: 372.219
• Mol file: 199452-41-0.mol

Synonyms:piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester

Chemical Property of piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester

There total 4 articles about piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

piperidine (110-89-4) + 6-Bromo-5-methyl-8-nitro-1,4-dihydro-benzo[d][1,3]oxazin-2-one (186267-77-6) → piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester (199452-41-0)

Guidance literature:

In tetrahydrofuran; for 8h; Ambient temperature;

DOI:10.1021/jo9707491

Reference yield:

2-amino-6-methylbenzyl alcohol (65658-16-4) → piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester (199452-41-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / Et₃N / tetrahydrofuran; toluene / 16 h / Ambient temperature

2: 94 percent / Br₂ / acetic acid; trifluoroacetic acid / 5 h

3: 99 percent / conc. H₂SO₄, KNO₃ / 18 h / Ambient temperature

4: 67 percent / tetrahydrofuran / 8 h / Ambient temperature

With sulfuric acid; bromine; potassium nitrate; triethylamine; In tetrahydrofuran; acetic acid; toluene; trifluoroacetic acid;

DOI:10.1021/jo9707491

Reference yield:

5-methyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one (186267-75-4) → piperidine-1-carboxylic acid 2-amino-5-bromo-6-methyl-3-nitrobenzyl ester (199452-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / Br₂ / acetic acid; trifluoroacetic acid / 5 h

2: 99 percent / conc. H₂SO₄, KNO₃ / 18 h / Ambient temperature

3: 67 percent / tetrahydrofuran / 8 h / Ambient temperature

With sulfuric acid; bromine; potassium nitrate; In tetrahydrofuran; acetic acid; trifluoroacetic acid;

DOI:10.1021/jo9707491

upstream raw materials:

piperidine

6-Bromo-5-methyl-8-nitro-1,4-dihydro-benzo[d][1,3]oxazin-2-one

2-amino-6-methylbenzyl alcohol

5-methyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one