(E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one

Base Information

• Chemical Name: (E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one
• CAS No.: 101979-53-7
• Molecular Formula: C₁₇H₂₁NO₂S₂
• Molecular Weight: 335.491

Synonyms:(E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one

Chemical Property of (E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one

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Technology Process of (E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one

There total 3 articles about (E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(E)-3-phenylpropenal (14371-10-9) + (S)-3-acetyl-4-isopropyl-1,3-thiazolidine-2-thione (101979-45-7) → (E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one (101979-53-7) + (E,R)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one (101979-49-1)

Guidance literature:

(S)-3-acetyl-4-isopropyl-1,3-thiazolidine-2-thione; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -40 ℃; for 2h;

(E)-3-phenylpropenal; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1021/ol0493960

Reference yield: 79.0%

(E)-3-phenylpropenal (14371-10-9) + C8H12NOS2(1-)*3Cl(1-)*Ti(4+) → (E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one (101979-53-7) + (E,R)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one (101979-49-1)

Guidance literature:

In dichloromethane; at -78 ℃; for 0.166667h; Yield given;

DOI:10.1016/S0040-4039(96)02055-2

Reference yield: 61.0%

(E)-3-phenylpropenal (14371-10-9) + (S)-3-acetyl-4-isopropyl-1,3-thiazolidine-2-thione (101979-45-7) → (E,S)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-phenylpent-4-en-1-one (101979-53-7)

Guidance literature:

With phenylborondichloride; (-)-sparteine; In dichloromethane; at -78 ℃; for 0.25h;

DOI:10.1016/j.tet.2004.08.008

upstream raw materials:

(E)-3-phenylpropenal

(S)-3-acetyl-4-isopropyl-1,3-thiazolidine-2-thione

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