2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

Base Information

Chemical Name:2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil
CAS No.:18892-65-4
Molecular Formula:C₂₈H₂₃FN₂O₄
Molecular Weight:470.5
Hs Code.:

Synonyms:2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

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Technology Process of 2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

There total 5 articles about 2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 101039-89-8
1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)-5-fluorouracil

: 18892-65-4
2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

: 101039-91-2
2,3'-anhydro-3-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

: 101039-92-3
1-(3-azido-2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranonosyl)-5-fluorouracil

: 101039-90-1
1-(3-azido-2,3-dideoxy-5-O-trityl-β-D-erythro-pentofuranosyl)-5-fluorouracil

Guidance literature:: With lithium azide; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

Reference yield:

: 101039-89-8
1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)-5-fluorouracil

: 18892-65-4
2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

Guidance literature:: With sodium hydroxide; In ethanol; at 90 ℃; for 0.166667h;
DOI:10.1080/15257770.2019.1610891

Reference yield:

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 18892-65-4
2,3'-anhydro-1-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-fluorouracil

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 0.5 h / 100 °C

1.2: 2 h / 20 °C

2.1: sodium hydroxide / ethanol / 0.17 h / 90 °C

With pyridine; sodium hydroxide; In ethanol;
DOI:10.1080/15257770.2019.1610891