4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene

Base Information

• Chemical Name: 4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene
• CAS No.: 381670-66-2
• Molecular Formula: C₂₂H₃₁Cl₂NOSi
• Molecular Weight: 424.486
• Mol file: 381670-66-2.mol

Synonyms:4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene

Chemical Property of 4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene

There total 1 articles about 4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

triisopropylsilyl chloride (13154-24-0) + 4-cyano-4-(3',4'-dichlorophenyl)cyclohexanone (65619-30-9) → 4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene (381670-66-2)

Guidance literature:

4-cyano-4-(3',4'-dichlorophenyl)cyclohexanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

triisopropylsilyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1016/S0040-4020(01)00796-7

Reference yield: 32.0%

4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene (381670-66-2) → 4-cyano-4-(3,4-dichlorophenyl)cyclohex-2-enone (381670-62-8)

Guidance literature:

With ammonium cerium(IV) nitrate; In N,N-dimethyl-formamide; at 0 ℃; for 18h;

DOI:10.1016/S0040-4020(01)00796-7

Reference yield:

4-cyano-4-(3',4'-dichlorophenyl)-1-(triisopropylsilyloxy)cyclohexene (381670-66-2) → 5-cyano-5-(3',4'-dichlorophenyl)-4,5-dihydro-3H-oxepin-2-one (381670-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / (NH₄)2Ce(NO₃)6 / dimethylformamide / 18 h / 0 °C

2: 80 percent / urea hydrogen peroxide; Na₂HPO₄; trifluoroacetic anhydride / CH₂Cl₂ / 12 h / 20 °C

With disodium hydrogenphosphate; ammonium cerium(IV) nitrate; urea hydrogen peroxide; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)00796-7

upstream raw materials:

triisopropylsilyl chloride

4-cyano-4-(3',4'-dichlorophenyl)cyclohexanone

Downstream raw materials:

4-cyano-4-(3,4-dichlorophenyl)cyclohex-2-enone

5-cyano-5-(3',4'-dichlorophenyl)-4,5-dihydro-3H-oxepin-2-one