4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol

Base Information

Chemical Name:4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol
CAS No.:1062671-34-4
Molecular Formula:C₂₁H₂₆N₄OS
Molecular Weight:382.53
Hs Code.:

Synonyms:4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol

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Chemical Property of 4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol

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Technology Process of 4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol

There total 3 articles about 4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1062671-36-6
{-4-[5-(4-benzyloxy-3-ethyl-5-methyl-phenyl)-[1,3,4]thiadiazol-2-yl]-6-methyl-pyridin-2-yl}-diethyl-amine

: 1062671-34-4
4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol

Guidance literature:: With hydrogen bromide; acetic acid; In ethyl acetate; at 20 - 60 ℃; for 72h;

Reference yield:

: 1063398-40-2
2-diethylamino-6-methyl-isonicotinic acid

: 1062671-34-4
4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 0.25 h / 110 °C / Microwave irradiation

3.1: hydrogen bromide / acetic acid; ethyl acetate / 56 h / 20 - 60 °C

With Lawessons reagent; hydrogen bromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate;

Reference yield:

: 1010113-45-7
4-benzyloxy-3-ethyl-5-methylbenzoic acid hydrazide

: 1062671-34-4
4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,3,4]thiadiazol-2-yl]-2-ethyl-6-methyl-phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 0.25 h / 110 °C / Microwave irradiation

3.1: hydrogen bromide / acetic acid; ethyl acetate / 56 h / 20 - 60 °C

With Lawessons reagent; hydrogen bromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate;