N,N'-Dibenzylphthalamide

Base Information

• Chemical Name: N,N'-Dibenzylphthalamide
• CAS No.: 38228-99-8
• Molecular Formula: C22H20N2O2
• Molecular Weight: 344.413
• Hs Code.: 2924299090
• NSC Number: 25019
• DSSTox Substance ID: DTXSID80282221
• Nikkaji Number: J839.005C
• Wikidata: Q82016441
• Mol file: 38228-99-8.mol

Synonyms:N,N'-Dibenzylphthalamide;38228-99-8;1-N,2-N-dibenzylbenzene-1,2-dicarboxamide;N1,N2-Dibenzylphthalamide;NSC25019;starbld0004876;Oprea1_311791;SCHEMBL11901003;N,N'-Dibenzylphthalamide, 95%;DTXSID80282221;NSC 25019;NSC-25019;STK368217;AKOS001268933;N,N'-dibenzylbenzene-1,2-dicarboxamide;Benzene-1,2-dicarboxamide, N,N'-dibenzyl-;CS-0332499;A836851;N1,N2-bis(phenylmethyl)benzene-1,2-dicarboxamide;Z199467040

Chemical Property of N,N'-Dibenzylphthalamide

Chemical Property:

• Melting Point: 154-156 °C(lit.)
• Boiling Point: 634 °C at 760 mmHg
• Flash Point: 224.3 °C
• PSA: 58.20000
• Density: 1.181g/cm³
• LogP: 4.32840
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 344.152477885
• Heavy Atom Count: 26
• Complexity: 411

Purity/Quality:

99% ^*data from raw suppliers

N,N′-Dibenzylphthalamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNC(=O)C2=CC=CC=C2C(=O)NCC3=CC=CC=C3

Technology Process of N,N'-Dibenzylphthalamide

There total 38 articles about N,N'-Dibenzylphthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-p-tolylsulfonyloxyphthalimide (56530-39-3) + benzylamine (100-46-9) → N,N'-dibenzylphthalamide (38228-99-8) + N-benzyl-2-(3-benzylureido)benzamide (2164-88-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2010.01.074

Reference yield: 98.0%

benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5) + benzylamine (100-46-9) → N,N'-dibenzylphthalamide (38228-99-8)

Guidance literature:

In xylene; for 7.5h; Heating;

DOI:10.1021/je00030a035

Reference yield: 94.0%

N-(2-mesitylenesulfonyloxy)phthalimide (124706-40-7) + benzylamine (100-46-9) → N,N'-dibenzylphthalamide (38228-99-8) + N-benzyl-2-(3-benzylureido)benzamide (2164-88-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2010.01.074

upstream raw materials:

N-propylphthalimide

benzylamine

Phthaloyl dichloride

phthalic acid dimethyl ester

Refernces

• 1、 -. "MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS". Paragraph 00395. . Retrieved 2017/09/05.
• 2、 Li, Xiangqian,Liang, Xiaomeng,Song, Ting,Su, Pengchen,Zhang, Zhichao. "Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2". . p. 5738 - 5746. Retrieved 2015/02/02.