tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate
CAS No.:1428478-71-0
Molecular Formula:C₁₈H₂₆BrNO₃
Molecular Weight:384.313
Hs Code.:

Synonyms:tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 139290-70-3
tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 1428478-71-0
tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

Guidance literature:: 1-bromomethyl-4-bromobenzene; With magnesium; In diethyl ether; at 0 - 10 ℃; for 0.5h; Reflux;

tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate; In tetrahydrofuran; diethyl ether; at 10 ℃; for 2h;

Reference yield:

: 1428478-71-0
tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

: 631-61-8,92206-38-7
ammonium acetate

: 1428478-72-1
tert-butyl 4-{[-4-(acetylamino)phenyl]acetyl}piperidine-1-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 6h; Inert atmosphere; Reflux;

Reference yield:

: 1428478-71-0
tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

: 1428477-74-0
5-[2-(4-{1-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate / methanol; ethyl acetate / 0.5 h

3: potassium hydroxide / ethanol; water / 24 h / Reflux

4: sodium azide / ethanol / 1.5 h / 60 - 70 °C

5: hydrogenchloride / ethyl acetate / 0.5 h

6: sodium cyanoborohydride; acetic acid / methanol; dichloromethane / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium azide; palladium diacetate; sodium cyanoborohydride; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;