1-[Diethoxyphosphoryl(ethoxy)methoxy]ethane

Base Information

• Chemical Name: 1-[Diethoxyphosphoryl(ethoxy)methoxy]ethane
• CAS No.: 17997-33-0
• Molecular Formula: C9H21 O5 P
• Molecular Weight: 240.237
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID00403678
• Wikidata: Q82207412
• Mol file: 17997-33-0.mol

Synonyms:17997-33-0;1-[diethoxyphosphoryl(ethoxy)methoxy]ethane;Diethyl diethoxymethylphosphonate;Diethyl(diethoxymethyl)phosphonate;diethyl (diethoxymethyl)phosphonate;Phosphonic acid, P-(diethoxymethyl)-, diethyl ester;diethoxymethylphosphonic acid diethyl ester;SCHEMBL8949832;DTXSID00403678;XUMKWCCJJRDWAO-UHFFFAOYSA-N;MFCD00102309;AKOS003600031;FT-0767488

Chemical Property of 1-[Diethoxyphosphoryl(ethoxy)methoxy]ethane

Chemical Property:

• Vapor Pressure: 0.00699mmHg at 25°C
• Refractive Index: 1.42
• Boiling Point: 279°Cat760mmHg
• Flash Point: 136.5°C
• PSA: 63.80000
• Density: 1.057g/cm³
• LogP: 2.60910
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 240.11266076
• Heavy Atom Count: 15
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

DIETHYL(DIETHOXYMETHYL)PHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(OCC)P(=O)(OCC)OCC

Technology Process of 1-[Diethoxyphosphoryl(ethoxy)methoxy]ethane

There total 21 articles about 1-[Diethoxyphosphoryl(ethoxy)methoxy]ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(diethoxymethyl)-2,2-diethoxy-4,5-dimethyl-1,3,2λ5-dioxaphospholene (115764-67-5) → diethyl(diethoxymethyl)phosphonate (17997-33-0)

Guidance literature:

With air; In dichloromethane; for 1.5h;

Reference yield: 89.0%

Diethyl phosphonate (762-04-9,123-22-8) + orthoformic acid triethyl ester (122-51-0) → diethyl(diethoxymethyl)phosphonate (17997-33-0)

Guidance literature:

With boron trifluoride diethyl etherate; at 120 ℃; for 1h;

Reference yield: 78.0%

C10H18N2O2 + diethyl trimethylsilyl phosphite (13716-45-5) → diethyl(diethoxymethyl)phosphonate (17997-33-0)

Guidance literature:

With chloro-trimethyl-silane; In dichloromethane; for 1h; Reflux; Inert atmosphere;

DOI:10.1002/hc.21353

upstream raw materials:

diethyl phosphorylchloridite

diethoxymethyl acetate

diethyl chlorophosphate

orthoformic acid triethyl ester

Downstream raw materials:

Diethoxymethyl-phosphonic acid 4-chloro-phenoxymethyl ester ethyl ester

Diethoxymethyl-phosphonic acid benzyl ester ethyl ester

S,S-dimethylthioacetal of diethyl oxomethanephosphonate

triethyl phosphonoformate

Refernces

• 1、 Prishchenko, Andrey A.,Alekseyev, Roman S.,Livantsov, Mikhail V.,Novikova, Olga P.,Livantsova, Ludmila I.,Terenin, Vladimir I.,Petrosyan, Valery S.. "Synthesis of new functionalized mono- and diphosphonic acids with five-membered aza-heterocycles moieties". . . Retrieved 2017.
• 2、 Gazizov,Khairullin,Karimova. "Reaction of P(III) chlorides with aldehydes: II. Reaction of primary intermediates with aprotic nucleophiles: Ethylene oxide, acetals, trialkyl orthoformates, and trialkyl phosphites". . p. 2293 - 2300. Retrieved 2014/03/21.