(1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

Base Information

Chemical Name:(1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]
CAS No.:1423035-86-2
Molecular Formula:C₂₃H₂₆N₂O₄S
Molecular Weight:426.536
Hs Code.:

Synonyms:(1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

Suppliers and Price of (1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

There total 8 articles about (1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154-09-6,526-53-4,2899-29-8,52485-52-6
L-tryptophanol

: 1423035-86-2
(1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

Guidance literature:: Multi-step reaction with 8 steps

1: toluene / 24 h / Dean-Stark; Reflux

2: sodium hydroxide; tetrabutyl-ammonium chloride / water; dichloromethane / 0 - 20 °C

3: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C

5: sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile; tert-butyl alcohol / 20 °C

6: tributylphosphine / dichloromethane / 16 h / Reflux

7: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / Reflux

8: lithium borohydride / diethyl ether / 48 h / Inert atmosphere; Reflux

With triethylsilane; sodium chlorite; sodium dihydrogenphosphate; lithium borohydride; 2,2'-azobis(isobutyronitrile); tributylphosphine; tetrabutyl-ammonium chloride; tri-n-butyl-tin hydride; titanium tetrachloride; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1039/c2cc38540f

Reference yield:

: 430461-02-2
dimethyl 3-(2-oxoethyl)pentan-1,5-dioate

: 1423035-86-2
(1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

Guidance literature:: Multi-step reaction with 8 steps

1: toluene / 24 h / Dean-Stark; Reflux

2: sodium hydroxide; tetrabutyl-ammonium chloride / water; dichloromethane / 0 - 20 °C

3: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C

5: sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile; tert-butyl alcohol / 20 °C

6: tributylphosphine / dichloromethane / 16 h / Reflux

7: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / Reflux

8: lithium borohydride / diethyl ether / 48 h / Inert atmosphere; Reflux

With triethylsilane; sodium chlorite; sodium dihydrogenphosphate; lithium borohydride; 2,2'-azobis(isobutyronitrile); tributylphosphine; tetrabutyl-ammonium chloride; tri-n-butyl-tin hydride; titanium tetrachloride; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1039/c2cc38540f

Reference yield:

: 1423035-80-6
(3S,7R,8aS)-7-(methoxycarbonylmethyl)-5-oxo-3-[1-(phenylsulfonyl)-3-indolylmethyl]-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 1423035-86-2
(1’S,7’S,8a’R)-7’-(2-hydroxyethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]

Guidance literature:: Multi-step reaction with 6 steps

1: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C

3: sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile; tert-butyl alcohol / 20 °C

4: tributylphosphine / dichloromethane / 16 h / Reflux

5: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / Reflux

6: lithium borohydride / diethyl ether / 48 h / Inert atmosphere; Reflux

With triethylsilane; sodium chlorite; sodium dihydrogenphosphate; lithium borohydride; 2,2'-azobis(isobutyronitrile); tributylphosphine; tri-n-butyl-tin hydride; titanium tetrachloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1039/c2cc38540f