2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine

Base Information

Chemical Name:2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine
CAS No.:1616293-82-3
Molecular Formula:C₂₃H₂₇N₅O₂
Molecular Weight:405.5
Hs Code.:

Synonyms:2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine

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Chemical Property of 2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine

Chemical Property:

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Technology Process of 2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine

There total 4 articles about 2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1616293-81-2
2-cyclopropyl-6,7-dimethoxy-4-[4-(2-nitro-phenyl)-piperazin-1-yl]-quinazoline

: 1616293-82-3
2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; for 2h; Inert atmosphere; Reflux;

Reference yield:

: 26759-46-6
methyl 2-amino-4,5-dimethoxybenzoate

: 1616293-82-3
2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 100 °C

2: trichlorophosphate / 110 °C

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C

4: iron; ammonium chloride / ethanol; water / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; iron; potassium carbonate; ammonium chloride; trichlorophosphate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 630422-37-6
2-cyclopropyl-6,7-dimethoxyquinazolin-4-ol

: 1616293-82-3
2-[4-(2-cyclopropyl-6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C

3: iron; ammonium chloride / ethanol; water / 2 h / Inert atmosphere; Reflux

With iron; potassium carbonate; ammonium chloride; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide;