2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide

Base Information

Chemical Name:2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide
CAS No.:1430476-04-2
Molecular Formula:C₁₉H₂₃N₃O₃S
Molecular Weight:373.476
Hs Code.:

Synonyms:2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide

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Chemical Property of 2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide

Chemical Property:

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Technology Process of 2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide

There total 4 articles about 2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1430476-03-1
1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)-2-(4-nitrophenyl)ethenesulfonamide

: 1430476-04-2
2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h; High pressure;
DOI:10.1016/j.bmcl.2013.02.109

Reference yield:

: 1430476-02-0
1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)methanesulfonamide

: 1430476-04-2
2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 2 h / 135 °C / Sealed tube

2: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / High pressure

With chloro-trimethyl-silane; palladium on activated charcoal; hydrogen; In methanol; N,N-dimethyl-formamide; 1: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.02.109

Reference yield:

: 67541-92-8
ethyl 2-(tert-butylaminosulfonyl)acetate

: 1430476-04-2
2-(4-aminophenyl)-1-(benzo[d]oxazol-2-yl)-N-(tert-butyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / water; tetrahydrofuran / 6 h / 0 - 20 °C

2: Lawessons reagent / 1 h / 150 °C / Sealed tube

3: chloro-trimethyl-silane / N,N-dimethyl-formamide / 2 h / 135 °C / Sealed tube

4: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / High pressure

With Lawessons reagent; chloro-trimethyl-silane; palladium on activated charcoal; hydrogen; potassium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 3: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.02.109