(3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one

Base Information

• Chemical Name: (3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one
• CAS No.: 188752-12-7
• Molecular Formula: C₃₂H₅₀O₆
• Molecular Weight: 530.745
• Mol file: 188752-12-7.mol

Synonyms:(3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one

Chemical Property of (3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one

There total 1 articles about (3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoprop-1-ene (557-93-7) + diisopropyl squarate (61699-62-5) + (2R,3R)-6-Bromo-2,3-dicyclohexyl-1,4-dioxa-spiro[4.4]non-6-ene → (3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one (188752-12-7) + (3aR,6aR,7aR)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/ja964140d

Reference yield:

(3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one (188752-12-7) → (R)-Methoxy-phenyl-acetic acid (3aS,3bR,4S,6aS,7aS)-4-hydroxy-2,3-diisopropoxy-7a-methyl-1-oxo-1,3b,4,5,6,6a,7,7a-octahydro-cyclopenta[a]pentalen-3a-yl ester

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / acetone; H₂O / 48 h / Ambient temperature

2: 94 percent / sodium borohydride / methanol

3: 33 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; water; acetone;

DOI:10.1021/ja964140d

Reference yield:

(3aS,6aS,7aS)-4-((1R,2R)-1,2-Dicyclohexyl-2-hydroxy-ethoxy)-3a-hydroxy-2,3-diisopropoxy-7a-methyl-3a,5,6,6a,7,7a-hexahydro-cyclopenta[a]pentalen-1-one (188752-12-7) → (R)-Methoxy-phenyl-acetic acid (3S,3aR,3bS,6aS,7aS)-3b-hydroxy-4,5-diisopropoxy-6a-methyl-6-oxo-2,3,3a,3b,6,6a,7,7a-octahydro-1H-cyclopenta[a]pentalen-3-yl ester (188752-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / acetone; H₂O / 48 h / Ambient temperature

2: 94 percent / sodium borohydride / methanol

3: 48 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; water; acetone;

DOI:10.1021/ja964140d

upstream raw materials:

2-bromoprop-1-ene

diisopropyl squarate

Downstream raw materials:

(R)-Methoxy-phenyl-acetic acid (3S,3aR,3bS,6aS,7aS)-3b-hydroxy-4,5-diisopropoxy-6a-methyl-6-oxo-2,3,3a,3b,6,6a,7,7a-octahydro-1H-cyclopenta[a]pentalen-3-yl ester