(E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid

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Chemical Name:(E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid
CAS No.:615252-66-9
Molecular Formula:C₁₇H₁₄ClNO₃
Molecular Weight:315.756
Hs Code.:

Synonyms:(E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid

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Chemical Property of (E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid

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Technology Process of (E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid

There total 2 articles about (E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2142-68-9
1-(2-chlorophenyl)ethanone

: 615252-64-7
ethyl 3-(4-formyl-1-methyl-1H-pyrrol-2-yl)-2-propenoate

: 615252-66-9
(E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 24h;
DOI:10.1021/jm049002a

Reference yield:

: 1192-58-1
N-methylpyrrole aldehyde

: 615252-66-9
(E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / ethanol / 80 °C

2.1: oxalyl chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C

2.2: 74 percent / 1,2-dichloro-ethane / 1 h / 20 °C

3.1: aq. KOH / ethanol / 24 h / 20 °C

With potassium hydroxide; oxalyl dichloride; potassium carbonate; In ethanol; 1,2-dichloro-ethane; 2.1: Vilsmeier-Haack reaction;
DOI:10.1021/jm034167p

Reference yield: 58.0%

: 615252-66-9
(E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid

: 3-{4-[3-(2-chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-N-hydroxy-acrylamide

Guidance literature:: (E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With hydroxylamine; In tetrahydrofuran; methanol; at 20 ℃; for 0.25h;
DOI:10.1021/jm034167p