(S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide

Base Information

Chemical Name:(S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide
CAS No.:228246-68-2
Molecular Formula:C₂₂H₂₇N₃O
Molecular Weight:349.476
Hs Code.:

Synonyms:(S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide

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Chemical Property of (S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide

Chemical Property:

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Technology Process of (S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide

There total 6 articles about (S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[4-cyano-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidin-4-yl]-N-phenyl-formamide

: 228246-68-2
(S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide

Guidance literature:: With ammonium hydroxide; In tert-butyl alcohol; at 20 ℃; for 16h;
DOI:10.1021/jm991129q

Reference yield:

: 77542-18-8
1-methyl-1-ethyl-4-oxopiperidinium iodide

: 228246-68-2
(S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. K₂CO₃ / ethanol / 1 h / Heating

2: acetic acid / 1.5 h / 20 °C

3: acetic anhydride / 72 h / 20 °C

4: aq. NH₄OH; 33percent aq. H₂O₂ / 2-methyl-propan-2-ol / 16 h / 20 °C

With ammonium hydroxide; potassium carbonate; acetic acid; In ethanol; acetic anhydride; tert-butyl alcohol; 1: Substitution / 2: Addition / 3: Formylation / 4: Hydrolysis;
DOI:10.1021/jm991129q

Reference yield:

: 49800-23-9,32908-42-2
(S)-(-)-1,2,3,4-tetrahydro-1-naphthylamine hydrochloride

: 228246-68-2
(S)-4-phenylamino-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperidine-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. K₂CO₃ / ethanol / 1 h / Heating

2: acetic acid / 1.5 h / 20 °C

3: acetic anhydride / 72 h / 20 °C

4: aq. NH₄OH; 33percent aq. H₂O₂ / 2-methyl-propan-2-ol / 16 h / 20 °C

With ammonium hydroxide; potassium carbonate; acetic acid; In ethanol; acetic anhydride; tert-butyl alcohol; 1: Substitution / 2: Addition / 3: Formylation / 4: Hydrolysis;
DOI:10.1021/jm991129q