Technology Process of 2,4-bis((triisopropylsilyl)oxy)benzaldehyde
There total 1 articles about 2,4-bis((triisopropylsilyl)oxy)benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,4-Dihydroxybenzaldehyde;
With
2,6-dimethylpyridine;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
Inert atmosphere;
triisopropylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/acs.orglett.5b03285
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1055/s-0029-1216842
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere
4.1: triphenyl-arsane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere
4.2: 1 h / 0 °C / Inert atmosphere
5.1: 7,7’-di-trifluoromethyl VANOL; borane-THF; acetic acid / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere; Molecular sieve
5.2: 20 h / 20 °C / Inert atmosphere; Molecular sieve
6.1: potassium carbonate / methanol; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
With
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); borane-THF; triphenyl-arsane; 7,7’-di-trifluoromethyl VANOL; potassium tert-butylate; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1.1: |Horner-Wadsworth-Emmons Olefination / 4.1: |Suzuki Coupling / 5.1: |Diels-Alder Cycloaddition / 5.2: |Diels-Alder Cycloaddition;
DOI:10.1021/acs.orglett.5b03285
