N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine

Base Information

Chemical Name:N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine
CAS No.:876728-25-5
Molecular Formula:C₄₈H₃₈FN₅O₃S
Molecular Weight:783.926
Hs Code.:

Synonyms:N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine

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Chemical Property of N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine

There total 3 articles about N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 876728-24-4
N2,5'-O-ditrityl-8,2'-anhydro-8-mercapto-9-β-arabinofuranosylguanine

: 876728-25-5
N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine

Guidance literature:: With Nonafluorobutanesulfonyl fluoride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 65 ℃; for 20h;
DOI:10.1016/j.tetlet.2006.06.074

Reference yield:

: 76-83-5
trityl chloride

: 876728-25-5
N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NEt₃ / dimethylformamide / 2 h / 40 °C

2: 91 percent / perfluorobutanesulfonyl fluoride; i-Pr₂NEt / ethyl acetate / 20 h / 65 °C

With Nonafluorobutanesulfonyl fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.06.074

Reference yield:

: 37070-11-4
8,2'-anhydro-8-mercaptoguanosine

: 876728-25-5
N2,5'-O-ditrityl-8,2'-anhydro-3'-deoxy-3'-fluoro-8-mercapto-9-β-arabinofuranosylguanine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NEt₃ / dimethylformamide / 2 h / 40 °C

2: 91 percent / perfluorobutanesulfonyl fluoride; i-Pr₂NEt / ethyl acetate / 20 h / 65 °C

With Nonafluorobutanesulfonyl fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.06.074