2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

Base Information

Chemical Name:2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine
CAS No.:1384519-79-2
Molecular Formula:C₁₉H₁₉N₇O₅
Molecular Weight:425.404
Hs Code.:

Synonyms:2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

Chemical Property:

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Technology Process of 2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

There total 4 articles about 2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1384520-03-9
O⁽⁶⁾-allyl-2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

: 1384519-79-2
2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium benzenesulfonate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;
DOI:10.1021/jo300628y

Reference yield:

: 72409-24-6
2',3',5'-tri-O-(tert-butyldimethylsilyl)guanosine

: 1384519-79-2
2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: caesium carbonate / 2 h / 20 °C / Inert atmosphere

3: tert.-butylnitrite; trimethylsilylazide / dichloromethane / 25 h / -20 - 20 °C

4: copper(l) chloride / water; tert-butyl alcohol / 20 °C / Inert atmosphere

5: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 20 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium benzenesulfonate / tetrahydrofuran; methanol / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; trimethylsilylazide; sodium benzenesulfonate; caesium carbonate; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; copper(l) chloride; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo300628y

Reference yield:

: 1384520-27-7
O⁶-allyl-2-azido-2',3',5'-tri-O-(tert-butyldimethylsily)inosine

: 1384519-79-2
2-[4-(4-methylphenyl)-1,2,3-triazol-1H-yl]inosine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) chloride / water; tert-butyl alcohol / 20 °C / Inert atmosphere

2: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium benzenesulfonate / tetrahydrofuran; methanol / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium benzenesulfonate; triethylamine tris(hydrogen fluoride); copper(l) chloride; In tetrahydrofuran; methanol; water; tert-butyl alcohol;
DOI:10.1021/jo300628y