Technology Process of C20H20F3N5O3
There total 11 articles about C20H20F3N5O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: ammonia; hydrogen / ethanol / 21 h / 45 °C
2.1: 0.25 h / 20 °C
3.1: nitric acid; acetic anhydride / 20 h / 0 - 20 °C
4.1: hydrogenchloride; water / 18 h / Reflux
5.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 0 - 20 °C
6.1: palladium on activated charcoal; hydrogen / methanol / 20 h / 20 °C
7.1: water / methanol; acetonitrile / 1 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C
8.2: 3 h / 100 °C
9.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
10.1: N-ethyl-N,N-diisopropylamine / 20 °C
10.2: 0.5 h / 20 °C
With
hydrogenchloride; palladium on activated charcoal; ammonia; water; hydrogen; nitric acid; acetic anhydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2011.02.108
- Guidance literature:
-
N-[5-(2-aminoethyl)-1H-benzoimidazol-2-yl]-acetamide; C15H11F3N2O5;
With
N-ethyl-N,N-diisopropylamine;
at 20 ℃;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1016/j.bmcl.2011.02.108
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / 20 °C
2.2: 0.5 h / 20 °C
With
N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1016/j.bmcl.2011.02.108
