citalopram propanoic acid

Base Information

• Chemical Name: citalopram propanoic acid
• CAS No.: 91283-87-3
• Molecular Formula: C₁₈H₁₄FNO₃
• Molecular Weight: 311.312
• Mol file: 91283-87-3.mol

Synonyms:citalopram propanoic acid

Chemical Property of citalopram propanoic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of citalopram propanoic acid

There total 2 articles about citalopram propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-(5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)propanoate → citalopram propanoic acid (91283-87-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/anie.202007403

Reference yield:

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (64169-67-1) → citalopram propanoic acid (91283-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride; 15-crown-5 / tetrahydrofuran / 0.08 h / -78 °C

1.2: 3 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 15-crown-5; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.202007403

Reference yield: 83.0%

3,5-dimethyl-1H-pyrazole (67-51-6) + citalopram propanoic acid (91283-87-3) → 1-(3-(3,5-dimethyl-1H-pyrazol-1-yl)-3-oxopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/anie.202007403

upstream raw materials:

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile