(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine

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Chemical Name:(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine
CAS No.:1232397-16-8
Molecular Formula:C₂₁H₂₀N₄O₃
Molecular Weight:376.415
Hs Code.:

Synonyms:(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine

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Chemical Property of (7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine

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Technology Process of (7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine

There total 13 articles about (7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1232815-55-2
2-methylsulfinyl-7-phenyl-pyrrolo[2,1-f][1,2,4]triazine

: 24313-88-0
3,4,5-Trimethoxyaniline

: 1232397-16-8
(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 4h;
DOI:10.1021/ol2015237

Reference yield: 30.0%

: 1232397-16-8
(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine

Guidance literature:

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232397-16-8
(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 24 °C

2: 1-methyl-pyrrolidin-2-one / 4 h / 140 °C

3: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/ol2015237