2,6-dichloro-4-(dimethoxymethyl)pyridine

Base Information

Chemical Name:2,6-dichloro-4-(dimethoxymethyl)pyridine
CAS No.:1390656-62-8
Molecular Formula:C₈H₉Cl₂NO₂
Molecular Weight:222.071
Hs Code.:

Synonyms:2,6-dichloro-4-(dimethoxymethyl)pyridine

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Chemical Property of 2,6-dichloro-4-(dimethoxymethyl)pyridine

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Technology Process of 2,6-dichloro-4-(dimethoxymethyl)pyridine

There total 1 articles about 2,6-dichloro-4-(dimethoxymethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1390656-62-8
2,6-dichloro-4-(dimethoxymethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 5 h / 20 °C / Cooling with ice

2: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C

3: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux

With thionyl chloride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 1390656-62-8
2,6-dichloro-4-(dimethoxymethyl)pyridine

: 1390656-69-5
tert-butyl-4-(4-(7-(2,6-dichlorophenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: 1,4-dioxane / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 15 h / 120 °C

6.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 120 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

Reference yield:

: 1390656-62-8
2,6-dichloro-4-(dimethoxymethyl)pyridine

: 1390655-23-8
7-[(2,6-dichlorophenyl)amino]-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: 1,4-dioxane / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 15 h / 120 °C

6.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 120 °C / Inert atmosphere

7.1: hydrogenchloride; water / methanol

With hydrogenchloride; n-butyllithium; potassium tert-butylate; water; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;