2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate

Base Information

• Chemical Name: 2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate
• CAS No.: 1059572-95-0
• Molecular Formula: C₂₉H₃₂N₂O₄
• Molecular Weight: 472.584
• Mol file: 1059572-95-0.mol

Synonyms:2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate

Chemical Property of 2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate

There total 1 articles about 2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-tert-butyl 12a-methyl (4aS,12aR)-9-bromo-1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine-2,12a-dicarboxylate (1059572-89-2) + phenylboronic acid (98-80-6) → 2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate (1059572-95-0)

Guidance literature:

With sodium tetrachloropalladate(II); dicyclohexyl {2-sulfo-9-[3-(4-sulfophenyl)propyl]-9H-fluoren-9-yl}phosphonium hydrogen sulfate; potassium carbonate; In water; butan-1-ol; at 100 ℃; for 16h;

DOI:10.1055/s-2008-1067148

Reference yield: 95.0%

2-tert-butyl 12a-methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-2,12a-dicarboxylate (1059572-95-0) → methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-12a-carboxylate (1059573-20-4)

Guidance literature:

With trifluoroacetic acid; at 23 ℃; for 1h;

DOI:10.1055/s-2008-1067148

upstream raw materials:

2-tert-butyl 12a-methyl (4aS,12aR)-9-bromo-1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine-2,12a-dicarboxylate

phenylboronic acid

Downstream raw materials:

methyl (4aS,12aR)-1,2,3,4,4a,5,12,12a-octahydro-9-phenylpyrido[3,4-b]acridine-12a-carboxylate