Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

Base Information

Chemical Name:Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester
CAS No.:328381-91-5
Molecular Formula:C₃₀H₅₂O₅Si₂
Molecular Weight:548.911
Hs Code.:

Synonyms:Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

Suppliers and Price of Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

There total 5 articles about Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 328381-90-4
benzoic acid 3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-butyl ester

: 328381-89-1
(E)-(S)-6-(Benzothiazole-2-sulfonyl)-2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hex-4-en-1-ol

: 328381-91-5
Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

Guidance literature:: (E)-(S)-6-(Benzothiazole-2-sulfonyl)-2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hex-4-en-1-ol; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

benzoic acid 3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-butyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 3h;
DOI:10.1002/1521-3773(20001215)39:24<4612::AID-ANIE4612>3.0.CO;2-C

Reference yield:

: 328381-98-2
(S)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxybutyl benzoate

: 328381-91-5
Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / (COCl)2; DMSO; NEt₃ / CH₂Cl₂ / -78 °C

2.1: LDA / tetrahydrofuran / 0.08 h / -78 °C

2.2: 57 percent / tetrahydrofuran / 3 h / -78 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation;
DOI:10.1002/1521-3773(20001215)39:24<4612::AID-ANIE4612>3.0.CO;2-C

Reference yield:

: 3,4-bis-(tert-butyl-dimethyl-silanyloxy)-butan-1-ol

: 328381-91-5
Benzoic acid (4E,6E)-(3S,9S)-3,9-bis-(tert-butyl-dimethyl-silanyloxy)-10-hydroxy-6-methyl-deca-4,6-dienyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / NEt₃ / CH₂Cl₂ / -78 °C

2.1: 53 percent / aq. HF / acetonitrile

3.1: 91 percent / (COCl)2; DMSO; NEt₃ / CH₂Cl₂ / -78 °C

4.1: LDA / tetrahydrofuran / 0.08 h / -78 °C

4.2: 57 percent / tetrahydrofuran / 3 h / -78 - 20 °C

With oxalyl dichloride; hydrogen fluoride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetonitrile; 3.1: Swern oxidation;
DOI:10.1002/1521-3773(20001215)39:24<4612::AID-ANIE4612>3.0.CO;2-C