3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine

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Chemical Name:3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine
CAS No.:1190854-80-8
Molecular Formula:C₂₃H₃₀ClN₃O₄S
Molecular Weight:480.028
Hs Code.:

Synonyms:3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine

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Chemical Property of 3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine

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Technology Process of 3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine

There total 14 articles about 3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: C₂₃H₃₀ClN₃O₅S

: 1190854-80-8
3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine

Guidance literature:: C₂₃H₃₀ClN₃O₅S; With trifluoroacetic acid; In dichloromethane; at 10 - 35 ℃; for 1h;

Tetrahydro-4H-pyran-4-one; With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 10 - 35 ℃; for 14h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: C₁₈H₂₂ClN₃O₃S

: 1190854-80-8
3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm300864p

Reference yield:

: C₂₃H₃₀ClN₃O₅S

: 1190854-80-8
3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300864p