N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide

Base Information

Chemical Name:N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide
CAS No.:128495-69-2
Molecular Formula:BrH*C₁₉H₂₄FNO
Molecular Weight:382.316
Hs Code.:

Synonyms:N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide

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Chemical Property of N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide

Chemical Property:

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Technology Process of N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide

There total 5 articles about N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 128495-63-6
N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-methoxyphenyl)ethylamine

: 128495-69-2
N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide

Guidance literature:: With hydrogen bromide; at 125 - 130 ℃; for 3h;
DOI:10.1021/jm00171a014

Reference yield:

: 458-40-2
2-(3-fluoro-4-methoxyphenyl)ethan-1-amine

: 128495-69-2
N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / triethylamine / diethyl ether / 1 h / Ambient temperature

2: LiAlH₄ / diethyl ether / 4 h / Ambient temperature

3: triethylamine / diethyl ether / 1 h / Ambient temperature

4: 94 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

5: 86 percent / 48percent HBr / 3 h / 125 - 130 °C

With lithium aluminium tetrahydride; hydrogen bromide; triethylamine; In diethyl ether;
DOI:10.1021/jm00171a014

Reference yield:

: [2-(3-Fluoro-4-methoxy-phenyl)-ethyl]-propyl-amine

: 128495-69-2
N-n-propyl-N-(2-phenylethyl)-2-(3-fluoro-4-hydroxyphenyl)ethylamine hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / diethyl ether / 1 h / Ambient temperature

2: 94 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

3: 86 percent / 48percent HBr / 3 h / 125 - 130 °C

With lithium aluminium tetrahydride; hydrogen bromide; triethylamine; In diethyl ether;
DOI:10.1021/jm00171a014