D-Alanine, L-leucyl-

Base Information

• Chemical Name: D-Alanine, L-leucyl-
• CAS No.: 17664-98-1
• Molecular Formula: C9H18 N2 O3
• Molecular Weight: 202.254
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID20426304
• Nikkaji Number: J82.656A
• Mol file: 17664-98-1.mol

Synonyms:D-Alanine, L-leucyl-;H-LEU-D-ALA-OH;17664-98-1;(2R)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]propanoic acid;(2R)-2-[[(2S)-2-Azaniumyl-4-methylpentanoyl]amino]propanoate;(R)-2-((S)-2-Amino-4-methylpentanamido)Propanoic acid;N-L-Leucyl-D-alanine;DTXSID20426304;AKOS010842229

Chemical Property of D-Alanine, L-leucyl-

Chemical Property:

• PSA: 92.42000
• LogP: 1.04030
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 202.13174244
• Heavy Atom Count: 14
• Complexity: 216

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(C)C(=O)O)N
• Isomeric SMILES: C[C@H](C(=O)O)NC(=O)[C@H](CC(C)C)N

Technology Process of D-Alanine, L-leucyl-

There total 5 articles about D-Alanine, L-leucyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-benzyl (1-azido-4-methyl-1-oxopentan-2-yl)carbamate (76863-45-1) → L-Leu-D-Ala (17664-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: NaOH; aqueous acetone / Hydrolysis_.Hydrogenolyse des Reaktionsprodukts an Palladium in Eisessig enthaltendem Methanol

With sodium hydroxide; diethyl ether; acetone;

Reference yield:

N-(N-benzyloxycarbonyl-L-leucyl)-D-alanine methyl ester (22221-80-3) → L-Leu-D-Ala (17664-98-1)

Guidance literature:

With sodium hydroxide; acetone; Hydrolysis_.Hydrogenolyse des Reaktionsprodukts an Palladium in Eisessig enthaltendem Methanol;

Reference yield:

N-benzyloxycarbonyl-L-leucine methyl ester (51021-87-5) → L-Leu-D-Ala (17664-98-1)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol; hydrazine hydrate / 20 °C

2: aqueous HCl; acetic acid; NaNO₂ / unter starker Kuehlung

3: diethyl ether

4: NaOH; aqueous acetone / Hydrolysis_.Hydrogenolyse des Reaktionsprodukts an Palladium in Eisessig enthaltendem Methanol

With hydrogenchloride; sodium hydroxide; diethyl ether; ethanol; hydrazine hydrate; acetic acid; acetone; sodium nitrite;

upstream raw materials:

N-(N-benzyloxycarbonyl-L-leucyl)-D-alanine methyl ester

N-benzyloxycarbonyl-L-leucine methyl ester

N-Z-Leucine chloride

(S)-benzyl (1-azido-4-methyl-1-oxopentan-2-yl)carbamate

Downstream raw materials:

D-Alanine

L-leucine