Technology Process of RGD-C2
There total 5 articles about RGD-C2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chlorotriisopropylsilane; water; trifluoroacetic acid;
at 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper(II) sulfate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C
3: chlorotriisopropylsilane; water; trifluoroacetic acid / 2.5 h / 20 °C
With
chlorotriisopropylsilane; water; benzotriazol-1-ol; copper(II) sulfate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C
1.2: 12 h
2.1: copper(II) sulfate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C
4.1: chlorotriisopropylsilane; water; trifluoroacetic acid / 2.5 h / 20 °C
With
chlorotriisopropylsilane; water; benzotriazol-1-ol; copper(II) sulfate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;